forty years ago, doctors learned why some patients who received the anesthetic succinylcholine awoke normally but remained temporarily paralyzed and unable to breathe: They shared an inherited quirk that slowed their metabolism of the drug. Later, scientists traced sluggish succinylcholine metabolism to a particular gene variant. Roughly 1 in 3500 people carry two deleterious copies, putting them at high risk of this distressing side effect.
在我看来,基因层面的治疗手段,在未来对人类健康的影响会越来越大,在许许多多的非基因问题和非基因治疗手段用尽了以后,剩下的命题,就只有基因治疗手段了
首先是「快速DNA测序(两周内)」,高通量测序(High-throughput sequencing)目前最便宜的已经低于100美金,最快的只要几十分钟就能完成一个人的全基因组测序,最便捷的只需要一个手提设备就可以完成
其次是 CRISPR-Cas9 基因剪切技术的不断完善:
再就是人类和引起人类疾病的物种之间的斗争也已经展开,比尔盖茨就很热衷对蚊子进行基因编程,以消除蚊子带给人的疾病风险:
相信在未来很长一段时间,我们会在基因层面和人类这一碳基生物的疾病做斗争